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Why Do We Forget Things? It May Make The Mind More Efficient

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In the quest to fend off forgetfulness, some people build a palace of memory. It’s a method for memorizing invented in ancient times by (legend has it) the Greek poet Simonides of Ceos, more recently made popular by multiple best-selling books (and the “mind palace” of Benedict Cumberbatch’s Sherlock Holmes).

Memory palaces provide imaginary architectural repositories for storing and retrieving anything you would like to remember. Sixteen centuries ago, St. Augustine spoke of “treasures of innumerable images” stored in his “spacious palaces of memory.” But twenty-first century scientists who study memory have identified an important point to remember: Even the most luxurious palace of memory needs trash cans.

Far from signifying failure, forgetting may be the brain’s frontline strategy in processing incoming information.

“There are memories that we don’t want and we don’t need,” says neuroscientist Maria Wimber. “Forgetting is good and an adaptive thing.”

Traditionally, forgetting has been regarded as a passive decay over time of the information recorded and stored in the brain. But while some memories may simply fade away like ink on paper exposed to sunlight, recent research suggests that forgetting is often more intentional, with erasure orchestrated by elaborate cellular and molecular mechanisms. And forgetfulness is not necessarily a sign of a faulty memory. “In fact,” Wimber says, “it’s been shown over and over in computational models and also in animal work that an intelligent memory system needs forgetting.”

Far from signifying failure, forgetting may be the brain’s frontline strategy in processing incoming information. Forgetting is essential, some researchers now argue, because the biological goal of the brain’s memory apparatus is not preserving information, but rather helping the brain make sound decisions. Understanding how the brain forgets may offer clues to enhancing mental performance in healthy brains while also providing insights into the mechanisms underlying a variety of mental disorders.

A graph conceived by the 19th century German psychologist Hermann Ebbinghaus quantified the decay of memory over time. Modern researchers use this graph to illustrate the competition between memory strengthening (or consolidation, blue arrows) and processes that degrade and weaken memories (forgetting, pink arrows). In this example, recall is strong (a peak percentage is retained) after about two days of acquiring a memory. Afterwards the memory rapidly decays for about two days and then begins to stabilize as consolidation balances forgetting.

A graph conceived by the 19th century German psychologist Hermann Ebbinghaus quantified the decay of memory over time. Modern researchers use this graph to illustrate the competition between memory strengthening (or consolidation, blue arrows) and processes that degrade and weaken memories (forgetting, pink arrows). In this example, recall is strong (a peak percentage is retained) after about two days of acquiring a memory. Afterwards the memory rapidly decays for about two days and then begins to stabilize as consolidation balances forgetting.

Biology of Remembering

Memory itself is still something of a mystery, but it basically consists of physical changes in the brain that encode a representation of past experiences. Those memory traces — known as engrams — can be accessed to reconstruct the past, albeit imperfectly. Many experts believe that engrams are built by strengthening synapses — the sites where signals are transmitted between nerve cells, or neurons. Recalling a memory reactivates a pattern of nerve cell signaling that mimics the original experience.

“The prevailing view is that the formation of an engram involves strengthening of synaptic connections between populations of neurons … that are active during an event,” Sheena Josselyn and Paul Frankland write in the current Annual Review of Neuroscience. “This increases the likelihood that the same (or similar) activity pattern within this cell assembly can be recreated at a later time.”

Engrams obviously do not save every detail of every experience. Some records of activity patterns do not persist. And that’s a good thing, says Wimber, of the University of Birmingham in England.

“An overly precise memory is maybe not really what we want in the long term, because it prevents us from using our memories to generalize them to new situations,” she said in San Diego at a recent meeting of the Society for Neuroscience. “If our memories are too precise and overfitted, then we can’t actually use them to … make predictions about future situations.”

If your memory stores every exact detail of getting bitten by a dog in the park, for instance, then you wouldn’t necessarily know to beware of a different dog in a different park. “In fact,” Wimber says, “what we might want is a more flexible and more generalized memory and that would involve a bit of forgetting of the details and more the development of a gist of a memory.”

Such “streamlined” memories are not side effects of flaws or constraints on memory power, Frankland and Blake Richards pointed out in a paper in Neuron in 2017. Such simplification “is an essential component of adaptive memory,” they wrote. “Simple memories that store the gist of our experiences and avoid complicated details will be better for generalizing to future events.”

Getting the gist, and just the gist, is therefore valuable as an aid to making smart decisions, say Frankland, of the Hospital for Sick Children in Toronto, and Richards, of the University of Toronto. In fact, they believe it is wrong to think of memory “simply as a means for high-fidelity transmission of information through time.” Rather, they propose that “the goal of memory is to guide intelligent decision making.”

Getting just the gist is especially helpful in changing environments, where loss of some memories improves decision making in several ways. For one thing, forgetting can eliminate outdated information that would hamper sound judgment. And memories that reproduce the past too faithfully can impair the ability to imagine differing futures, making behavior too inflexible to cope with changing conditions. Failure to forget can result in the persistence of unwanted or debilitating memories, as with post-traumatic stress disorder.

Active Forgetting

Forgetting’s great value implies that it doesn’t happen accidentally. In some cases, forgetting may simply reflect an inability to recall a memory trace even if the engram encoding it remains intact. But a growing number of researchers believe that can’t be the whole story. As Ronald Davis and Yi Zhong point out, the brain’s remarkable storage ability suggests that it possesses an efficient information management system, equipped with data disposal methods. “Because of the extraordinary large number of memory engrams that can accumulate in the brain across time, it seems logical that the brain must have … mechanisms to remove memories that become unused,” they wrote in 2017 in Neuron.

Psychologists have considered the possibility of active forgetting for more than half a century, but only in the last 15 years or so have researchers accumulated substantial neurobiological evidence on the issue. While the neuroscientific study of forgetting is still in its infancy, scientists have begun to discern some of the brain’s tactics for information erasure. In their paper in Neuron, Davis, of Scripps Research Institute Florida, and Zhong, of Tsinghua University in Beijing, described various studies in the last few years on mechanisms that may implement the forgetting process.

When memories are acquired (upper left), traces of the memory are stored by molecular changes in networks of cells, forming an engram. Memories stored in engrams can be forgotten “passively” by different processes (lower left), such as loss of contextual cues permitting retrieval of the memory, interference with retrieval by other similar memories, or simply the decay of unstable biological materials in the engram cells. Some researchers believe “active” forgetting may be more potent at erasing memory than the passive mechanisms. Several forms of active forgetting have been proposed, including intentional attempts to suppress unpleasant memories (motivated forgetting); forgetting of some parts of a memory by retrieval of other parts; decay of memory induced by interference from other information processing; and “intrinsic” forgetting — erasure of information by cells and biochemical processes as an essential part of the brain’s memory apparatus for managing information efficiently.

When memories are acquired (upper left), traces of the memory are stored by molecular changes in networks of cells, forming an engram. Memories stored in engrams can be forgotten “passively” by different processes (lower left), such as loss of contextual cues permitting retrieval of the memory, interference with retrieval by other similar memories, or simply the decay of unstable biological materials in the engram cells. Some researchers believe “active” forgetting may be more potent at erasing memory than the passive mechanisms. Several forms of active forgetting have been proposed, including intentional attempts to suppress unpleasant memories (motivated forgetting); forgetting of some parts of a memory by retrieval of other parts; decay of memory induced by interference from other information processing; and “intrinsic” forgetting — erasure of information by cells and biochemical processes as an essential part of the brain’s memory apparatus for managing information efficiently.

Some forgetting does appear to be “passive” — a result of either natural decay of the biological material forming engrams or the loss of ability to retrieve them, Davis and Zhong noted. But many forms of forgetting are more like running a program that wipes data off your hard drive. New stimuli can actively interfere with old memories, for instance. Recalling parts of a memory can induce loss of other parts of it. And “forgetting cells” might actually signal the brain to sweep memory traces away, Davis and Zhong suggested. “We posit that … the brain also has the inherent biological capacity to erode memory traces using signaling systems” similar to those used in acquiring memories and storing them. In fact, forgetting could be the brain’s main strategy in managing information.

“I would speculate that forgetting might be the default system of the brain,” Davis said at the neuroscience meeting. “We might have a slow chronic forgetting signal in our brains that basically says let’s erase everything unless a judge … comes to intervene and says this memory is worth saving.”

In various experimental studies, Davis and others have amassed ample evidence for the role of biochemical processes that actively erase memory. Studies in fruit flies, for instance, implicate the well-known chemical messenger molecule dopamine.

Flies can remember to avoid an odor that has been accompanied by an electric shock, a memory managed by nerve cells known as mushroom body neurons. Shocks activate other neurons that transmit dopamine to the mushroom body cells, initiating biochemical reactions that store a memory linking the shock to the odor. But that memory is soon forgotten (typically by the next day). Something erases it, and the evidence suggests dopamine is responsible for the forgetting, too.

Dopamine’s dual role is not fully understood. But mushroom body neurons possess two distinct molecular antennas that respond to dopamine; one of those antennas (or receptor molecules) initiates memory formation, the other promotes erasure. Whether dopamine promotes or erases memory may depend on the context, including prevailing biochemical conditions and how active the mushroom body neuron is at the time.

Fruit flies remember to fear an odor if its presence is accompanied by an electric shock. That memory forms because the shock stimulates the release of the molecule dopamine from nerve cells linked to mushroom body neurons at the same time that the odor triggers a cellular signal (via calcium). When stimulated by dopamine, a “molecular antenna” or receptor molecule (dDA1) on the mushroom body neuron initiates chemical reactions (via the cAMP signaling molecule) that restructure the mushroom body neuron, strengthening the memory. Recall fades over time as, in the absence of the odor, lower levels of dopamine stimulate another dopamine receptor molecule (DAMB), leading to a weakening of the memory.

Fruit flies remember to fear an odor if its presence is accompanied by an electric shock. That memory forms because the shock stimulates the release of the molecule dopamine from nerve cells linked to mushroom body neurons at the same time that the odor triggers a cellular signal (via calcium). When stimulated by dopamine, a “molecular antenna” or receptor molecule (dDA1) on the mushroom body neuron initiates chemical reactions (via the cAMP signaling molecule) that restructure the mushroom body neuron, strengthening the memory. Recall fades over time as, in the absence of the odor, lower levels of dopamine stimulate another dopamine receptor molecule (DAMB), leading to a weakening of the memory.

In any case, the erasing process involves a protein known as Rac1, which plays a part in structuring synapses. Restructuring synapses in response to Rac1 may be responsible for weakening engrams, some studies indicate. Blocking Rac1 activity, for example, helps to extend how long memories persist.

Rac1 may also be involved in a second forgetting mechanism, driven by the birth of new nerve cells (the process known as neurogenesis). Studies in rats have found that new neurons integrated into existing neural circuits can restructure the circuitry. Such changes in connections might make memories harder to access, Frankland said at the neuroscience meeting. Animal studies have shown that disrupting neurogenesis preserves memories, while high levels of neurogenesis drive forgetting. Whether that form of forgetting is important in humans remains unknown, as the amount of neurogenesis in adult humans is still an unsettled question.

In any case, the evidence suggests that many types of “forgetting cells” must be involved in erasing engrams. “Dozens of molecular and cellular pathways likely exist to erode memories,” Davis and Zhong wrote in Neuron.

How and when those processes operate can depend on various factors, such as physical activity, stress and sleep. Sleep is known to enhance memory in humans and other animals, presumably by providing a time when memories can be stored (or “consolidated”) in the brain. But sleep may also aid memory by suppressing the processes that drive forgetting, Davis and Zhong point out. A 2015 study published in Cell found evidence that sleep inhibits release of the dopamine forgetting signal to mushroom body neurons.

If forgetting is the key to how the brain successfully processes the massive data input it encounters each day — as research accumulated so far suggests — then flaws in the forgetting process could plausibly contribute to brain disorders, Davis and Zhong note. Deficits in the ability to forget may be involved in autism spectrum disorders, for instance. Certainly the powerful and debilitating memories of post-traumatic stress disorder reflect an inability to forget disturbing experiences. Unwanted, repetitive invasive memories are a feature of some psychiatric disorders, such as schizophrenia. And the inability to forget cues associated with addictive drug use impairs recovery from substance abuse.

On the plus side, better insight into the biology of forgetting could help identify drugs capable of enhancing needed memories while disposing of undesirable ones. But such benefits may appear only after much more research, Davis said at the neuroscience meeting — speaking at a rather sparsely attended session.

“We’re at the very, very beginning of trying to understand the neurobiology of active forgetting,” he said. But he expects that the field will rapidly attract more attention.

“I guarantee you five years from now this room will be filled,” he said. “Hordes of neuroscientists will start invading this field.” If he’s right, future meetings on forgetting might best be convened at a spacious palace — with plenty of trash bins and perhaps even a dumpster.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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Ecology

Yukon and Northern BC First Nations tackle climate change using Indigenous knowledge and science

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YUKON, June 18, 2021 /CNW/ – The Government of Canada is working together in partnership with Indigenous and Northern communities in finding solutions to adapt to the impacts of climate change in the North.

Today, Minister of Northern Affairs, Daniel Vandal, along with Parliamentary Secretary to the Minister of Economic Development and Official Languages (Canadian Northern Economic Development Agency), Larry Bagnell, highlighted progress on three unique, Indigenous-led projects that are helping communities in Yukon and Northern British Columbia adapt to the challenges posed by climate change.

The Minister and Parliamentary Secretary met virtually with Carcross/Tagish First Nation (C/TFN) to learn about their community-led climate change monitoring program. C/TFN has partnered with Tsay Keh Dene Nation (TKDN) and Chu Cho Environmental of Prince George, British Columbia, to build a community-led monitoring project that examines environmental data and Indigenous knowledge to create a holistic picture of how the climate is changing across C/TFN and TKDN traditional territories. The project combines tracking of current and historical climate trends with knowledge shared by Elders while also providing opportunities for youth mentorship and climate change awareness.

The Taku River Tlingit First Nation (TRTFN) is also leading a unique project to assess the impacts of climate change within their traditional territory. Climate change is causing many of the culturally significant ice patches to melt, exposing organic artifacts to oxygen and leading to rapid deterioration. The TRTFN ice patch mapping project will involve performing archaeological assessments to prevent the degradation of artifacts. Research will be guided by traditional knowledge, Elders and oral histories, when available, and heavily involve community, Elders, youth and Knowledge Keepers.

The Pelly Crossing Selkirk Development Corporation is leading the Selkirk Wind Resource Assessment project through the installation of a Sonic Detection and Ranging (SODAR) system. The initiative includes a feasibility study leading up to the construction of a renewable energy facility, including wind, solar and battery energy storage. Expanding clean energy within the region will have direct benefits for communities, including reduced reliance on diesel, job creation and revenue generation for Selkirk First Nation. 

These projects are delivering important environmental, social and economic benefits that lead to healthier, more sustainable and resilient communities across Yukon and Northern British Columbia. They also build community clean energy capacity and help to avoid the impacts of climate change.

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Ecology

Atlantic Provinces Ready For Aquaculture Growth

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Aquaculture is an important economic driver for rural, coastal and Indigenous communities, and Atlantic Canada is well positioned to increase aquaculture production as global demand for sustainably sourced seafood grows.

That is why the ministers responsible for aquaculture in the Atlantic provinces have agreed to the ongoing development and management of their industries based on common principles. A new memorandum of understanding has been signed by the four ministers, which extends the previous agreement signed in 2008.

“In a time when food security is especially important, it is good to see our aquaculture industry has grown steadily and is poised for continued growth in 2021 based on environmentally responsible, science-based policies and practices,” said Keith Colwell, Minister of Fisheries and Aquaculture for Nova Scotia. “Our Atlantic partnership continues to help the industry grow sustainably.”

Cooperation between the provinces and the aquaculture industry has led to improvements in pest management, environmentally sustainable aquaculture methods, aquatic animal health and policies to support the shared use of marine and freshwater resources. It also aims to align regulation and policy between the provinces to make the regulatory requirements easier to understand by industry and the public.

Each province has a comprehensive and robust legislative and regulatory framework to ensure environmental sustainability, economic prosperity and public accountability. The provinces update their legislation and regulations regularly. Nova Scotia revamped its regulatory framework in 2015; New Brunswick received Royal Assent for a new Aquaculture Act in 2019 and is working on the supporting regulations; Newfoundland and Labrador completely revised its aquaculture policy in 2019; and Prince Edward Island has recently drafted a new Aquaculture Act.

The ministers have agreed to continue to use science-based evidence for management decisions, thereby increasing public and investor confidence in the Atlantic Canadian aquaculture industry.

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COMING SOON: A Healthy Environment and a Healthy Economy 2.0

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We all want the same thing: a clean and responsible energy future for our children and future generations while continuing to enjoy a high standard of living.

On December 11, 2020, the Prime Minister announced a new climate plan which he claimed will help achieve Canada’s economic and environmental goals.

The proposed plan by Environment and Climate Change Canada (ECCC) entitled “A Healthy Environment and a Healthy Economy” will have an initial investment of $15 billion of taxpayer’s money. It is built on 5 pillars of action:

  1) Making the Places Canadians Live and Gather More Affordable by Cutting Energy Waste

2) Making Clean, Affordable Transportation and Power Available in Every Community

3) Continuing to Ensure Pollution isn’t Free and Households Get More Money Back

4) Building Canada’s Clean Industrial Advantage

5) Embracing the Power of Nature to Support Healthier Families and More Resilient Communities  

In my paper, “A Healthy Environment and a Healthy Economy 2.0” I will objectively critique each pillar in the government’s new climate plan and provide alternative solutions to the same issues.

  This is an alternative plan that supports workers, protects lower income earners and creates economic growth while respecting the environment and focusing on the dignity of work.

  This plan abandons virtue-signaling projects and relies on Canadian ingenuity to build our economy and restore Canada’s role of responsible leadership in the world.

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